Oxidative Stress
Biologic systems contain redox elements, which function in cell signaling, macromolecular trafficking and physiologic regulation1. Oxidative stress includes disruption of this redox circuitry through altered functions of enzymes, receptors, transporters, transcription factors, and structural elements, in addition to the macromolecular damage, both resulting from an imbalance between pro-oxidants and antioxidants performances
LabOmics offers easy and affordable kits and probes to assess oxidative stress in biological samples or in cultured cells.
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Carboxy-H2DCFDA ROS indicator145,00 €ROS indicator, Ex/Em = 495/529 nm. Carboxy-H2DCFDA [5-(and 6)-Carboxy-2′,7′-dichlorodihydrofluorescein diacetate] is a chemically reduced analogue of fluorescein used as an indicator for reactive oxygen species (ROS) in cells. Upon cleavage of the acetate groups by intracellular esterases and oxidation, the nonfluorescent Carboxy-H2DCFDA is converted to the highly fluorescent 5-(and 6)-carboxy-2',7'-dichlorofluorescein, with additional negative charges that impede its leakage out of the cell. Learn More