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A key application for TALEs is the targeted activation and repression of target genes in cells by fusing transactivation domains to TALE DNA binding domains . The TALE-TF construct is a powerful tool to selectively modulate gene expression in eukaryotic c Learn More

AAVS1 CRISPR system designed to integrate a gene of interest or any other genetic element into the AAVS1 safe harbor site in human chromosome 19 via homologous recombination. Learn More

RNA-Guided ENdonucleases (RGENs) are novel, programmable genome engineering tools that were developed from bacterial adaptive immune machinery. In this system—the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) i Learn More

TAL Effector nucleases (TALENs) are artificial restriction enzymes, created by fusing an engineered TAL DNA binding domain (which targets a desired sequences) with the DNA cleavage domain of FokI, a type II restriction enzyme. Learn More

Zinc finger nucleases (ZFNs) are artificial restriction enzymes, created by fusing an engineered zinc finger DNA binding domain (which targets a desired sequences) with the DNA cleavage domain of FokI, a type II restriction enzyme. Learn More

Donor plasmid design and synthesis for Knock-In (KI) and Gene Correction through Homologous Recombination (HR). To be used with engineered nucleases (ZFNs, TALENs and RGENs/CRISPRs) Learn More

AAVS1 CRISPR system designed to integrate a gene of interest or any other genetic element into the AAVS1 safe harbor site in human chromosome 19 via homologous recombination. Learn More

Genome-TALER™ human AAVS1 safe harbor gene targeting kit is designed to specifically transfer your gene of interest, selection marker or other genetic element from a donor plasmid into the AAVS1 safe harbor site in human chromosome 19 via TALEN-mediated homologous recombination Learn More

AAVS1 TALEN pair (TN-AAVS1) AAVS1 donor cloning vector (DC-DON-SH01) AAVS1 positive control donor (DC-RFP-SH01) knock-in verification primer pairs (HQPAVSHR) Learn More

AAVS1 safe harbor gene targeting-RGEN (CRISPR) kit-ToolGen-RNP format: AAVS1 integration system that avoids any possible integration of sgRNA/Cas9 DNA expression vectors Learn More