The knocking down (KD) effect of the shRNA clones for a single gene can be studied and compared with that of a scrambled nucleotide control clone which is included for free with every shRNA clone order.
Genes have been grouped into various signal transduction, metabolic, and disease pathways and associations, as well as gene families and groups. By arraying the shRNA clones of known pathway(s) in 96 or 384 well plates, the role for a group of genes can be studied in a pathway. Large collection of shRNA clones against the human kinome is available which can be grouped according to the functionality of each kinase.
The OmicsLink™ expression ready ORF cDNA clones together with the same ORF clones that contain silent mutations in shRNA target sequence regions can be used for shRNA validation studies and gene/protein functional rescue studies for genes/proteins targeted by corresponding shRNA.
How to order
1. Identify the gene of interest:
Please gather as much as possible of the following information: Gene Description, species, Nucleotide Accession, Entrez Gene ID, Symbols/Aliases or Catalog/product ID. You can also submit a sequence so we can search by target gene sequences homology (BLAST)
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Vector based shRNA technology. Collection of shRNA expression clones available in both regular mammalian expression vector psi-H1™ and lentiviral expression systems (psiLv-H1™ and psiLV-U6™), which enables both transient and stable gene silencing. A mamma Learn More